Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

Blog Article

Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-dependent phospholipid peroxidation.Ferroptosis plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation, immunity, and chronic injuries.The inhibitors against ferroptosis easton speed comp -13 effectively improve iron homeostasis, lipid metabolism, redox finish line thia cal stabilization, neuronal remodeling, and functional recovery after trauma.

In this review, we elaborate on the latest molecular mechanisms of ferroptosis, emphasize its role in secondary central nervous trauma, and update the medicines used to suppress ferroptosis following injuries.